The Buffalo Bills have looked like one of the best teams in the league over the past month, but while they could win the AFC East by beating Miami, a defeat could see them miss out on the play-offs completely.
Quarterback Josh Allen has been back playing at MVP level but Miami have a high-powered attack and want a first division title since 2008 - plus the winner will grab the second seed and at least two home play-off games, which is a crucial advantage.
The Green Bay Packers will make the play-offs if they win at home against the Chicago Bears - who they have beaten in nine straight games - while a defeat leaves them looking for a ton of help.
Chicago have been in good form the second half of the season though and Justin Fields is playing to convince his team not to use the top pick of the 2024 Draft on a new quarterback.
His opposite number Jordan Love would love to succeed where Aaron Rodgers failed last season, when the Packers lost to the Lions in a similar scenario. The game at Lambeau Field is live on BBC Radio 5 Sports Extra from 21:00 GMT.
Both Houston and Indianapolis have improved dramatically this year but it is the Texans and impressive rookie quarterback CJ Stroud who advanced to the play-offs on Saturday night as he led his team to a tense 23-19 victory over the Colts.
Stroud threw two touchdowns and the Texans defence held on to end the Colts' season and give Houston a chance of winning the AFC South - if the Jacksonville Jaguars lose on Sunday.
And it may not be easy for the Jaguars as they are still sweating over the fitness of their star quarterback Trevor Lawrence before the game against the Tennessee Titans.
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